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Nature Chemical Biology

These actions were inhibited by an HGF antagonist and a short hairpin RNA targeting c-Met

Sterile water has no preservative

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects